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At Fluxion, we’re passionate about delivering cell-based and cell-free solutions that facilitate the transformation of research discoveries into new ways to diagnose and treat patients. By characterizing molecular and cellular mechanisms of disease, Fluxion’s platforms help bridge the translational medicine gap, enabling rapid advances in disease research, drug discovery, and the development of diagnostic tests.

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Different Flow Conditions Modulate Anti-Thrombotic Effects and Mechanisms of Xueshuantong Capsule

Speakers: Dr. Fulong Liao & Dr. Yun You, Department of Biomechanopharmacology, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

Abstract

Anti-thrombosis Effects and Mechanisms by Xueshuantong Capsule Under Different Flow Conditions

Xueshuantong capsule (XST) is a patented traditional Chinese medicine used for the prevention and treatment of thrombosis. The molecular mechanism of the anti-thrombotic effect of XST was investigated through the crosstalk among the platelets/leukocytes, endothelial cells (ECs), and flow shear stress. The BioFlux 1000z system was employed to generate two levels of shear stress conditions: 0.1 and 0.9 Pa. BioFlux Montage cell analysis software was used to analyze the adhesion cell numbers. Effects of XST on inhibiting platelet activation and suppressing platelets/leukocytes adhesion to injured ECs are not only concentration-dependent, but also shear stress dependent. Furthermore, we wonder whether effects of XST on shear-induced platelet aggregation are associated with Piezo1 protein, the potential mechanotransduction-module. The BioFlux 1000z system and high shear 48-well plates are utilized, and the microfluidic channels are coated with vWF.

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