Speaker: Nathan Blood, University of Sheffield
Abstract:
Flow dynamics & material surface properties influence ureolytic biofilm development & encrustation: studies into biofilm formation by Proteus mirabilis
Catheter blockage by ureolytic biofilm-forming pathogens is a significant problem for health services, with an estimated cost of £1-2.5bn along with 2,000 deaths in the UK alone each year. Resolving this issue will require a deeper understanding of the fundamental processes and mechanisms involved in catheter biofilm formation.
In the SCARAB labs (University of Sheffield, UK) we are using the BioFlux 1000Z to study ureolytic Proteus mirabilis biofilms in catheter-like flow environments, aiming to uncover some of the key factors influencing biofilm development and catheter blockage. Preliminary work presented in this webinar shows both surface- and flow-dependent growth phenotypes, indicating an important role for both of these in biofilm formation.
