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At Fluxion, we’re passionate about delivering cell-based and cell-free solutions that facilitate the transformation of research discoveries into new ways to diagnose and treat patients. By characterizing molecular and cellular mechanisms of disease, Fluxion’s platforms help bridge the translational medicine gap, enabling rapid advances in disease research, drug discovery, and the development of diagnostic tests.

Modeling catheter-blocking biofilms using the BioFlux system

Speaker: Nathan Blood, University of Sheffield

Abstract:

Flow dynamics & material surface properties influence ureolytic biofilm development & encrustation: studies into biofilm formation by Proteus mirabilis

Catheter blockage by ureolytic biofilm-forming pathogens is a significant problem for health services, with an estimated cost of £1-2.5bn along with 2,000 deaths in the UK alone each year. Resolving this issue will require a deeper understanding of the fundamental processes and mechanisms involved in catheter biofilm formation.
In the SCARAB labs (University of Sheffield, UK) we are using the BioFlux 1000Z to study ureolytic Proteus mirabilis biofilms in catheter-like flow environments, aiming to uncover some of the key factors influencing biofilm development and catheter blockage. Preliminary work presented in this webinar shows both surface- and flow-dependent growth phenotypes, indicating an important role for both of these in biofilm formation.

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