At Fluxion, we’re passionate about delivering cell-based and cell-free solutions that facilitate the transformation of research discoveries into new ways to diagnose and treat patients. By characterizing molecular and cellular mechanisms of disease, Fluxion’s platforms help bridge the translational medicine gap, enabling rapid advances in disease research, drug discovery, and the development of diagnostic tests.
Speaker: Dr. Patrick Hines, MD/PhD, Pediatric Critical Care Medicine Physician, Pulmonary Hypertension Specialist, and Vascular Biology Research Scientist
Abstract: James Herrick first described the “Peculiar Elongated and Sickle-Shaped Red Blood Corpuscles in a Case of Severe Anemia” in 1910. Linus Pauling discovered the molecular basis for sickle cell disease (SCD) in 1949. Since these landmark discoveries, there has only been one FDA-approved therapy for the prevention of SCD-related complications. Fortunately, this is a historic moment in sickle cell discovery with the largest pipeline of promising SCD-specific drugs in preclinical and clinical trials in the history of the disease. In addition to targeting hemoglobin polymerization, many of these drugs target the unique erythrocyte adhesive properties that contribute to microvascular obstruction. Despite this, there is no clinical standard for assessing erythrocyte adhesion. SCD providers will soon have drugs available to prevent and relieve adhesion-mediated complications, therefore there is an urgent need diagnostic tools to guide drug selection for individual patients and monitor therapeutic response. Dr. Hines has used flow adhesion models to understand the adhesive properties of sickle erythrocytes in a simulated blood flow environment, and has worked to standardize this process for clinical testing. He recently founded Functional Fluidics, a startup company that has deployed a standardized microfluidic flow-based test into the preclinical and clinical research market. Dr. Hines will discuss advancements in microfluidic flow-based blood function testing, the role that these tests are play in preclinical drug validation, and the potential for applications in sickle cell clinical trials and ultimately clinical therapy.