At Fluxion, we’re passionate about delivering cell-based and cell-free solutions that facilitate the transformation of research discoveries into new ways to diagnose and treat patients. By characterizing molecular and cellular mechanisms of disease, Fluxion’s platforms help bridge the translational medicine gap, enabling rapid advances in disease research, drug discovery, and the development of diagnostic tests.
Paralytic shellfish poisoning (PSP) is a serious risk to human consumption of mollusks. Considering that the main target for these toxins is Nav channels, most studies screening for these compounds focused on binding assays instead of patch clamp. A study from Universidad de Santiago de Compostela in Spain focused on developing a screening assay for toxicity equivalence factors of PSP analogs using automated patch clamp (APC). Using an IonFlux system and established Nav cell lines, they showed the viability of using an APC in fulfilling deficiencies in other analytical methods and establishing a suitable setup for PSP screening. The study investigated Nav 1.1, 1.2, 1.3, 14, 1.5, 1.6 and 1.7 with nine PSP standards.