At Fluxion, we’re passionate about delivering cell-based and cell-free solutions that facilitate the transformation of research discoveries into new ways to diagnose and treat patients. By characterizing molecular and cellular mechanisms of disease, Fluxion’s platforms help bridge the translational medicine gap, enabling rapid advances in disease research, drug discovery, and the development of diagnostic tests.
The IonFlux system's unique capabilities allow for the execution of otherwise very difficult assays. Its distinctive characteristics with fast in-plate solution exchange, continuous flow of external buffers, and best-in-class temperature control, permit not only fast screening of ion channel activity but also non-traditional assays such as analysis of cell membrane conductivity in the presence of external stressors. Below are some examples demonstrating the range of flexibility IonFlux systems provide:
Dr. Haiyang (David) Wei from Eurofins presented the abilities of data from IonFlux HT showing current stability, plate-to-plate reproducibility, agonists & antagonists effects, open channel block, PAM effects, binding kinetics, and recovery from desensitization. The presentation can be seen at the Ion Channel Retreat 2014 web site: Presentation at the Ion Channel Retreat
Recently presented webinars focusing on assays ranging from screening of nicotinic compounds to toxin effects on potassium channels can be viewed at the Molecular Devices web site: Webinars presented at Molecular Devices